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Disorders related to excessive alcohol use, other drug use or use of other substances including caffeine and tobacco that is characterized by an inability to control or limit the amount taken or the frequency; intense cravings; continuing use despite problems with work, school or family/social obligations or interpersonal problems; risky use, e.g., driving a car, operating machinery while under the influence or continuing to smoke following an emphysema diagnosis; or evidence of pharmacological indicators (tolerance and withdrawal symptoms), the adjustment the body makes as it attempts to adapt to the continued and frequent use of a substance.